Related Products of 104197-14-0, A common heterocyclic compound, 104197-14-0, name is 4-Bromo-2,6-difluoroanisole, molecular formula is C7H5BrF2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 4 2.5-Difluoro-4-methoxy-benzaldehyde A mixture of 4-bromo-2,6-difluoroanisole (4.46 g, 20.0 mmol), toluene (200 mL), and THF (10 mL) was cooled to -78 C. To the mixture was added n-BuLi (8.00 mL of a 2.5 M solution in hexanes, 20 mmol). After stirring at -78 C. for 1 h, DMF (3.10 ml, 40.0 mmol) was added. The mixture was stirred at -78 C. for 2 h and then H2O (100 mL) was added. After warming to rt, the mixture was extracted with EtOAc (2*75 mL). The combined extracts were dried (MgSO4), filtered and concentrated to provide 3.00 g of 2,5-difluoro-4-methoxy-benzaldehyde as a solid. 1H NMR (400 MHz, CDCl3): delta 10.18 (d, 1, J=2.9), 7.54 (dd, 1, J=10.6, 6.4), 6.72 (dd, 1, J=11.4, 6.4), 3.95 (s, 3).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Pfizer Inc; US2006/58361; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem