Adding a certain compound to certain chemical reactions, such as: 31576-51-9, name is 2-(2-Methoxyethoxy)ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31576-51-9, Computed Properties of C5H13NO2
A mixture of 2- (5-amino-2- (furan-2-yl) -7H-pyrazolo [4, 3-e] [1, 2, 4] triazolo [1, 5-c] pyrimidin-7-yl) -2-phenylpropanoic acid (100 mg, 0.2570 mmol) , 2- (2-methoxyethoxy) ethan-1-amine (37 mg, 0.3085 mmol) , HATU (146 mg, 0.3856 mmol) , DIPEA (99 mg, 0.7712 mmol) in DMF (3 mL) was stirred at rt for 3 hours. The reaction mixture was poured into H 2O (10 mL) and extracted with EtOAc (15 mL x 3) . The combined organic layer was washed with brine, dried over Na 2SO 4, concentrated and purified by column chromatography (DCM/MeOH=40: 110: 1) to give the target product (85 mg, 67.48%) . 1HNMR (400 MHz, DMSO-d6) delta 8.24 (s, 1H) , 7.98 (s, 2H) , 7.95 (s, 1H) , 7.56 (t, J = 5.6 Hz, 1H) , 7.34 -7.22 (m, 4H) , 7.15 (dd, J = 7.7, 1.5 Hz, 2H) , 6.74 (dd, J = 3.3, 1.8 Hz, 1H) , 3.46 -3.37 (m, 4H) , 3.29 (dd, J = 5.6, 3.0 Hz, 3H) , 3.22 (dd, J = 13.2, 6.0 Hz, 1H) , 3.13 (s, 3H) , 2.28 (s, 3H) . MS: M/e 491 (M+1) +.
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Reference:
Patent; BEIGENE, LTD.; ZHANG, Guoliang; ZHOU, Changyou; (152 pag.)WO2019/196803; (2019); A1;,
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