Reference of 148583-65-7, These common heterocyclic compound, 148583-65-7, name is 4-Fluoro-2-isopropoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 9 1-(4-Fluoro-2-methylethoxyphenyl)piperazine (XXI) A crude solution of XX (8.35 g, 47.9 mmol), bis-(2-choroethyl)amine hydrochloride (12.83 g, 71.9 mmol) and triethylamine (10.00 mL, 71.7 mmol) in chlorobenzene (70 mL) was heated at reflux for 25 h. The dark brown reaction mixture was then partitioned between 3N NaOH and methylene chloride. The organic layer was separated, dried (MgSO4), filtered and concentrated to yield 15.9 g of a brown oil.
The synthetic route of 148583-65-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; McNeilab, Inc.; US5569659; (1996); A;,
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