1484-26-0, name is 3-Benzyloxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 1484-26-0
Phenyl [3-(benzyloxy)phenyl]carbamate; To a stirred solution of 3-benzyloxyaniline (0.999 g, 5.01 mmol) in DCM (10 piL) was added pyridine (1.22 ml, 15.03 mmol) and phenyl chloroformate (0.68 ml, 5.51 mmol) dropwise (Exotherm.). The reaction was then allowed to stir at room temperature for 2 hours. The reaction mixture was then partitioned between DCM and IM HCl, extracted twice, combined organics passed through phase separating cartridge and filtrate evaporated to dryness to give an orange solid. This was then triturated in 10percent ethyl acetate/ hexanes, filtered and dried to give the product, phenyl [3-(benzyloxy)phenyl]carbamate, as beige solid (1.209 g, 3.78 mmol, 75percent yield).
The synthetic route of 1484-26-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/67401; (2006); A1;,
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