Reference of 578-57-4, A common heterocyclic compound, 578-57-4, name is 1-Bromo-2-methoxybenzene, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 186 mg (1mmol) 2 – bromoanisole, 186 mg (2mmol) aniline, 9.05 mg (0.05mmol) Cu (OAc)2, 36.1 mg (0.1mmol) ligand L3, 489mg (1.5mmol) Cs2CO3, 2 ml MeOH, adding 10 ml reaction tube, sealing, 60 C reaction under the condition of 3h. After the stop of the reaction, water, extracted with ethyl acetate, washing, saturated salt water washing, after drying with anhydrous sodium sulfate, filtered, the filtrate is distilled under reduced pressure, purification by silica gel chromatography separation column column, shall be 2 – methoxy – N – phenylaniline 175 mg, yield 88%.
The synthetic route of 578-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sun Yat-sen University; Wan Yiqian; Ding Xiaomei; Huang Manna; Zhu Xinhai; Yi Zhou; CN106883132; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem