Some common heterocyclic compound, 261762-35-0, name is 5-Bromo-1,2-difluoro-3-methoxybenzene, molecular formula is C7H5BrF2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: ethers-buliding-blocks
To the reaction vessel of 3000 L was added the above-obtained 2,3-difluoro-5-bromoanisole and 215 kg of AlCl3,And then pumped into 1800L of toluene,Sealed reactor, heated to reflux after 5h sampling analysis,Raw materials have been basically complete.The material with nitrogen into the 5000L washing kettle,Pumped into 1000L water stirring washing, discard the water layer,And then repeated washing once a few layers into the distillation kettle,After the toluene was distilled off, it was distilled under reduced pressure to obtain 206.1 kg of 2,3-difluoro-5-bromophenol,The product content of GC was 99.4%.The recovered toluene can be reused after drying. The total yield of the two-step reaction was 82.2%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 261762-35-0, its application will become more common.
Reference:
Patent; Zhejiang Linjiang Chemical Industry Co., Ltd.; Yi, Miao; Yin, Xin; Chen, Huanjun; Wang, Qijin; Xu, Xin; (8 pag.)CN106478377; (2017); A;,
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