Related Products of 93919-56-3,Some common heterocyclic compound, 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, molecular formula is C8H8F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Amino-3,5-difluorobenzoic acid (500 mg; 2.89 mmol), 10 ml of dry DCM, and TEA (1.61 ml; 11.55 mmol) were placed in a reaction flask under nitrogen. 4- (Trifluoromethoxy)benzylamine (0.529 ml; 3.47 mmol) was added slowly and then T3P (3.4 ml; 5.78 mmol; 50 % in EtOAc) was added keeping the temperature at rt. The mixture was stirred at rt overnight. The reaction mixture was diluted with DCM and washed three times with water. The organic phase was dried with a phase separator and evaporated to dryness to yield 1.09 g of 2-amino-3)5-difluoro-N-(4-(trifluoromethoxy)benzyl)benzamide. 1H-NMR (400 MHz, -DMSO): delta 3.33 (s, 6H), 4.45 (d, 2H), 6.24 (s, 2H), 7.22-7.40 (m, 4H), 7.41-7.51 (m, 2H), 9.02 (t, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-(Trifluoromethoxy)phenyl)methanamine, its application will become more common.
Reference:
Patent; ORION CORPORATION; PRUSIS, Peteris; HOeGLUND, Lisa; TOeRMAKANGAS, Olli; HIETANEN, Ari; ARVELA, Riina; VESALAINEN, Anniina; HEIKKINEN, Terhi; WO2015/169999; (2015); A1;,
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