Reference of 588-63-6,Some common heterocyclic compound, 588-63-6, name is (3-Bromopropoxy)benzene, molecular formula is C9H11BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: NaN3 (0.42 g, 6.5 mmol) was added to a stirred solution of 1-bromo-4-(3-bromopropoxy)benzene (1.47 g, 5 mmol) in DMSO (25 mL). The mixture was stirred for 12 h at room temperature, diluted with H2O (50 mL), and extracted by EtOAc (50 mL .x. 3). The organic layer was separated, dried with Na2SO4, and concentrated under reduced pressure. The residue was white solid and reacted to the next step without further purification. The synthetic method for the compound 5b was similar to the synthesis of compound 5a.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (3-Bromopropoxy)benzene, its application will become more common.
Reference:
Article; Wang, Shengzheng; Jin, Gang; Wang, Wenya; Zhu, Lingjian; Zhang, Yongqiang; Dong, Guoqiang; Liu, Yang; Zhuang, Chunlin; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian; Sheng, Chunquan; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 292 – 299;,
Ether – Wikipedia,
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