Application of 651734-54-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 651734-54-2 as follows.
Pd2dba3 (224mg; 0.245 mmol) and BINAP (305 mg; 0.49 mmol) was added to a solution of intermediate 25 (2g; 4.9 mmol), 2,6-difluoro-3,5-dimethoxyaniline (1.39g; 7.35 mmol) and Cs2003 (4.79g; 14.69 mmol) in dioxane (60 mL). The reaction mixture was heated overnight at 80C. Then, it was poured onto cooled water and the aqueous layer was extracted with DCM. The organic layer was dried over MgSO4, filtered and the solvent was evaporated. The resulting residue was cristallized from DIPE to afford 1.90g of intermediate 26 (75%).MP = 2600C (Kofler)
According to the analysis of related databases, 651734-54-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; ANGIBAUD, Patrick Rene; QUEROLLE, Olivier Alexis Georges; PILATTE, Isabelle Noelle Constance; MEERPOEL, Lieven; PONCELET, Virginie Sophie; WO2014/174307; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem