Reference of 645-36-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 645-36-3 as follows.
General procedure: The aromatic aldehyde or ketone and aminoacetaldehyde diethyl acetal were placed in a 500 mL round-bottom flask and toluene was added (see conditions in table 1 b). The mixture was heated under reflux in a Dean-Stark apparatus (around 4 h, see conditions in table 1 b) until complete separation of water was achieved. Toluene was then evaporated to give after drying the desired iminoacetal in almost quantitative yield. The iminoacetal ANP 31058A was prepared from 3,4-dimethoxybenzylamine (23.2 mmol) and pyruvic aldehyde dimethyl acetal (35.5 mmol) using the same general procedure (see conditions in table 1 b).
According to the analysis of related databases, 645-36-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALLERGAN, INC.; EXONHIT THERAPEUTICS SA; LEBLOND, Bertrand; BEAUSOLEIL, Eric; CASAGRANDE, Anne-Sophie; DESIRE, Laurent J.R.; PANDO, Matthew P.; DONELLO, John E.; YANG, Rong; TAVERNE, Thierry; CHAUVIGNAC, Cedric; WO2014/71044; (2014); A1;,
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