Adding a certain compound to certain chemical reactions, such as: 101-55-3, name is 1-Bromo-4-phenoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101-55-3, HPLC of Formula: C12H9BrO
(2) In a 500 ml four-necked flask, 3 g of 4-bromobiphenyl ether and 61 g of diethyl ether and 3.3 g of magnesium wire were put into a 500 ml four-necked flask under the protection of high-purity nitrogen, and Grignard reaction was initiated by rapid stirring at 35 C.,8 ~ 9 hours dropping 4-bromo-diphenyl ether 28g and80g ether solution,40 incubated for 2 hours, cooled to 5 , quickly added mixed coupling agent (cuprous iodide 1.5g, cuprous bromide 1.0g), continue to cool to -16 , temperature -16 ~ 20 ,(15 g of S-epichlorohydrin and 18 g of diethyl ether) was added dropwise for 10 to 11 hours and then incubated at -16 to 20 C for 15 hours, transferred to 65 g of 12% dilute sulfuric acid and stirred at 25 to 30 C for 1 hour,After standing for half an hour, the layers were separated and the ether was distilled and recovered. 120 g of water was added and the mixture was filtered while cooling to 5 C. The wet product was dried at 75 C for 2 hours to obtain (S) -1- (4-diphenylether) -2- Hydroxy-3-chloropropane yield 91.8%, content 95.1%. .
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Reference:
Patent; Binhai Extensive Chemical Co., Ltd.; Wu Fucai; (8 pag.)CN106957220; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem