Electric Literature of 6943-97-1, These common heterocyclic compound, 6943-97-1, name is 1-(3-Bromopropyl)-3-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 10.10: Intermediate 10.1.9: (S)-3 -tert-Butoxycarbonylamino- 1 , 1 -bis- [3 -(3 -methoxy-phenyl)-propyl] – piperidinium hydroxide Chiral (S)-Piperidin-3-yl-carbamic acid tert-butyl ester (2.72 g, 13.6 mmol) and l-(3-Bromo-propyl)-3-methoxy- benzene (6.6 g, 28.8 mmol), potassium carbonate (2.5 g, 18 mmol) and sodium iodide (4 g, 26.7 mmol) are dissolved in acetonitril (40 ml) and stirred at reflux for 1 day and the solvent is removed under vacuo. The residue is taken up in dichloromethane, filtered through a pad of silica, washed with a mixture of di- chloromethane:methanol: cone. ammonia = 4: 1 :0.1 and the filtrate is evaporated. LC (method L): tR = 1.30 min; Mass spectrum (ESI+): m/z = 497 [M]+.
Statistics shows that 1-(3-Bromopropyl)-3-methoxybenzene is playing an increasingly important role. we look forward to future research findings about 6943-97-1.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WIEDENMAYER, Dieter; HAMPRECHT, Dieter; HECKEL, Armin; WO2015/18754; (2015); A1;,
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