Reference of 1462-37-9, These common heterocyclic compound, 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3) 0.24 g (10 mmol) of sodium hydride and 15 ml of N, N-dimethylformamide were added to a 50 ml round bottom flask,Stirred at room temperature for 10 minutes,Then 2.5 g (10 mmol) of compound 2 and 10 mmol were added2-benzyloxyethyl bromide,And with thin layer chromatography to detect the end of the reaction,The reaction solution was then poured into 500 ml of ice water,Extracted three times with 100 ml of ethyl acetate,Combine organic phase,Evaporated solvent,The resulting residue was purified by silica gel column chromatography (V dichloromethane: V methanol = 100: 1)Compound 3 (2.7 g, yield 71%) was obtained.
The synthetic route of 1462-37-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangxi Normal University; Chen, Zhenfeng; Liang, Hong; Liu, Yancheng; Lu, Xing; Li, Liangping; (13 pag.)CN106432288; (2017); A;,
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