Synthetic Route of 39538-68-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39538-68-6 as follows.
To a solution of 3a (550 mg,4 mmol) in 3 mL concentrated HCl at 0 C was added NaNO2(320 mg, 4.6 mmol; dissolved in 5 mL H2O), and the mixture was stirred at 0 C for 1 h. A solution of KI (950 mg, 5.7 mmol; dissolvedin 10 mL H2O) was added dropwise at 0 C, and the mixture was slowly warmed up to room temperature overnight with stirring. The mixture was extracted with ether and the combined organic layers were washed with brine, dried over anhydrous MgSO4, and evaporated under reduced pressure. The residue was purified by silica gel flash chromatography (hexane as eluent) to give the titled product as colorless oil (0.826 g, 84% yield): 1H NMR (400 MHz, CDCl3) delta 7.62 (d, J=7.9 Hz, 1H), 6.65 (s, 1H), 6.55 (d, J=7.9 Hz, 1H), 3.87 (s, 3H), 2.33 (s, 3H).
According to the analysis of related databases, 39538-68-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Muppidi, Avinash; Doi, Kenichiro; Ramil, Carlo P.; Wang, Hong-Gang; Lin, Qing; Tetrahedron; vol. 70; 42; (2014); p. 7740 – 7745;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem