Application of 19500-02-8, These common heterocyclic compound, 19500-02-8, name is 3-Methoxy-2-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 1-methoxy-2-methyl-3-aminobenzene 15.0 g, triphosgene 48.7 g and toluene 350 mL was stirred withheating under ref lux for three hours. The reaction mixtures after standing to cool were condentrated under reduced pressure to give 1-methoxy-3-isocyanato-2- methylbenzene 17.0 g.?H NMR (CDC13) : 2.19(3H, S), 3.82(3H, 5), 6.69(1H, d, J=8.2Hz), 6.72(1H, dd, J=0.5, 8.0Hz), 7.09(1H, t, J=8.2Hz)
Statistics shows that 3-Methoxy-2-methylaniline is playing an increasingly important role. we look forward to future research findings about 19500-02-8.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; YOSHIMOTO, Yuya; TAKAHASHI, Teruki; OOHIRA, Daisuke; AZUMA, Shuhei; WO2013/162077; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem