Application of 79128-08-8, The chemical industry reduces the impact on the environment during synthesis 79128-08-8, name is 1,3-Diisopropoxybenzene, I believe this compound will play a more active role in future production and life.
2- (2-hydroxy-4-pyrrolidinylbenzoyl) benzoic acid(1-A, 0.015 mmol, synthesized by the method described in Kamino et al., Org. Lett., 2014, 16, 258)And 1,3-diisopropoxybenzene(2-D, 0.074 mmol, synthesized by the method described in Kamino et al., Biorg. Med. Chem. Lett., 2008, 18, 4380)Was added to methanesulfonic acid (5 mL), and the mixture was stirred at 110 C. for 24 hours. The reaction solution was made basic with saturated aqueous sodium hydrogen carbonate solution and extracted with chloroform.After drying the organic layer with magnesium sulfate, the solvent was distilled off under reduced pressure. The obtained crude product was dissolved in chloroform and subjected to silica gel column chromatography to separate the compound ABPX 105-a and the compound ABPX 105-b.At this time, the compound ABPX 105 – a had flowed out first, and then the compound ABPX 105 – b flowed out. The yield was 74% in total of ABPX 105-a and ABPX 105-b. The reaction formula is shown below.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Diisopropoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; RIKEN; Kamino, Shinichiro; Sawada, Daisuke; Enomoto, Shuichi; Watanabe, Chikara; (37 pag.)JP2017/88879; (2017); A;,
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