Electric Literature of 5111-65-9, These common heterocyclic compound, 5111-65-9, name is 2-Bromo-6-methoxynaphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
6-Methoxy-2-bromonaphthalene (0.97 g, 4.1 mmol) was dissolved in 20 mL of dry THF, protected under nitrogen, (3.4 mL, 8.2 mmol) was added, stirred for 1 hour, and then anhydrous DMF (0.941 mL, 12.3 mmol) was added dropwise at -78 C,The reaction was continued at 78 C for 1 hour, rose to room temperature, acidified to pH = 5 with 2N hydrochloric acid, extracted with ethyl acetate, washed with water, saturated brine Washed with anhydrous sodium sulfate, filtered and concentrated, n-hexane / ethyl acetate (15: 1) column chromatography to isolate 6-methoxy-2-naphthyl Aldehyde, the yield of 88.6%.
Statistics shows that 2-Bromo-6-methoxynaphthalene is playing an increasingly important role. we look forward to future research findings about 5111-65-9.
Reference:
Patent; Liaocheng University; Liu Guoyun; Yang Jie; Li Xiaoteng; Guo Shangjing; (19 pag.)CN105111054; (2017); B;,
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