These common heterocyclic compound, 592-55-2, name is 1-Bromo-2-ethoxyethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 592-55-2
2-(2-ethoxyethoxy)-1 ,3-dimethylidene-2,3-dihydro-1 H-isoindole (1-18) The N-hydroxypthalimide (4.0 g) and 1 -bromo-2-ethoxyethane (11 .25 g) were dissolved in DMF (40.0 ml) and CH3000Na (10.0 g) was added to the solution at room temperature. The reaction mixture was allowed to stir at 70 00 for 12 hours. Thereaction mixture was allowed to cool to room temperature and was and was poured in water and then extracted two times by ethyl acetate. The organic layer was concentrated under reduce pressure and was purified by column chromatography using silica gel. The desired product was eluted with 0-30% ethyl acetate in hexane. Evaporation of pure product fractions gave 4.8 g of 2-(2-ethoxyethoxy)-1 ,3-dimethylidene-2,3-dihydro-1H-isoindole (1-18) (Yield: 83.3 %). 1H-NMR (DMSO-d6): (ppm) 0.98 (t, 3H),3.39 (q, 2H), 3.73 (t, 2H), 4.27 (t, 2H), 7.87 (s, 4H). LC-MS: mlz= 236.2 (M+H).
The synthetic route of 1-Bromo-2-ethoxyethane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INFLECTIS BIOSCIENCE; GUEDAT, Philippe; (110 pag.)WO2016/1390; (2016); A1;,
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