Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33170-72-8, name is 2-Bromo-1,1-dimethoxypropane, A new synthetic method of this compound is introduced below., Recommanded Product: 33170-72-8
[0157] To a stirred solution of 3,5-bis(methylthio)-l ,2,4-triazin-6-amine (10.0 g, 53.19 mmol) and 2-bromo- 1 , 1 -dimethoxypropane (19.6 g, 319.14 mmol, 2 times added), in CH3CN (120 mL) was added (+/-)-camphor-10-sulfonic acid (3.70 gm, 15.95 mmol) and MS-4A (2 g). and the mixture was heated at 85 C for 40 h. The mixture was cooled to RT and concentrated under reduced pressure to reduce the volume to 30 mL. The obtained solid was filtered and washed with CH3CN (10 mL). The solid was dissolved in 20% MeOH in CH2CI2 and filtered, and the filtrate was concentrated under reduced pressure to afford 7- methyl-2,4-bis(methylthio)imidazo[l ,2-f][1,2,4]triazine as a pale brown solid (7 g, 58%). 1H NMR (300MHz, DMSO-J6) delta 7.59 (br s, IH), 2.63 (s, 3H), 2.60 (s, 3H), 2.48 (s, 3H); MS (ESI) m/z 227.12 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; KALYRA PHARMACEUTICALS, INC.; BUNKER, Kevin, Duane; ABRAHAM, Sunny; HOPKINS, Chad, Daniel; PINCHMAN, Joseph, Robert; HUANG, Peter, Qinhua; SLEE, Deborah, Helen; (122 pag.)WO2016/183094; (2016); A1;,
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