Electric Literature of 20059-73-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20059-73-8, name is 2-(4-(Aminomethyl)phenoxy)-N,N-dimethylethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1 1.5 kg of 4-(2-dimethylaminoethoxy)-benzylamine dissolved in sec-butanol and DMF obtained as described in the previous example are charged into a reactor and 12.7 kg of 37% hydrochloric acid are added dropwise. The pH is checked to ensure it is <1.0 and the precipitated mixture is stirred at 45-50C for at least 30 minutes. The mixture is cooled to 0-5C, centrifuged and the precipitate washed with 1 1.5 kg of sec-butanol. It is dried under vacuum at 70-80C. 13.5 kg of 4-(2- dimethylaminoethoxy)benzylamine dihydrochloride are obtained with HPLC purity higher than 98%. Reaction yield calculated on the 4-(2-dimethylaminoethoxy)- benzylamine 85.8%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-(Aminomethyl)phenoxy)-N,N-dimethylethanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ERREGIERRE S.p.A.; WO2006/51079; (2006); A1;,
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