Electric Literature of 39021-83-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of 1,4-dimethoxy-2,3-dimethylbenzene 1 (1.50 g, 9.0 mmol), N-bromosuccinimide (6.43 g, 36.1 mmol) and benzoyl peroxide (0.22 g, 0.9 mmol) in benzotrifluoride (220 cm3) was heated under reflux for 2.5 h and then allowed to cool and filtered. The filtrate was evaporated to give an orange residue, shown by 1H NMR and TLC to contain a mixture of the desired product 2 and the ring brominated product 8. Recrystallisation (petroleum ether/ethyl acetate, 3:1) gave the desired product 2 (1.03 g, 35%) as a pale yellow solid, mp and 1H NMR data as above.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dimethoxy-2,3-dimethylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Aitken, R. Alan; Jethwa, Siddharth J.; Richardson, Neville V.; Slawin, Alexandra M.Z.; Tetrahedron Letters; vol. 57; 14; (2016); p. 1563 – 1566;,
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