According to the analysis of related databases, 36805-97-7, the application of this compound in the production field has become more and more popular.
In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36805-97-7 as follows. Product Details of 36805-97-7
Example 678-Amino-1 -methyl -4,5-dihydro-1 H-1 ,7,9-triaza-cyclopentafa1naphthalene-2,3- dicarboxylic acid 2-tert-butyl ester 3 -ethyl ester (N6) To a solution of i-methyl^-oxo^AthetaJ-tetrahydro-I H-indole^S-dicarboxylic acid 2-tert- butyl ester 3-ethyl ester XXVIA (4.67 mmol) in DMF (20 ml_), N,N-dimethylformamide di- tert-butyl acetal (2 mL) was added and the solution was stirred at 1000C overnight. After cooling to rt guanidine hydrochloride (14 mmol) and K2CO3 (14 mmol) were added and the mixture was heated at 1000C for 24 h. The organic solvent was evaporated to dryness. Chromatography on silica gel (AcOEt/hexane 1 :1 ) afforded the title compound (80% yield). ESI (+) MS: m/z 373 (MH+). 1H NMR: 1.28 (t, J=7.07, 3H), 1.55 (s, 9H), 2.68 (t, J=7.80, 2H), 2.79 (t, J=7.80, 2H), 4.18 (s, 3H), 4.23 (q, J =7.07, 2H), 6.40 (bs, 2H), 7.97 (s, 1 H).
According to the analysis of related databases, 36805-97-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; WO2008/65054; (2008); A1;,
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