Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, A new synthetic method of this compound is introduced below., Safety of 3,5-Dimethoxyphenylacetylene
To a solution of 1.5 g (9.2 mmol) of 1-ethynyl-3,5-dimethoxybenzene and 2.16 g (9.2 mmol) of 4-iodoanisole in 10.0 mL of pyrrolidine, 64 mg (0.246 mmol) of triphenylphosphine and 27 mg (0.123 mmol) of Pd(OAc)2 were added. The mixture was stirred under an Ar stream and heated at reflux temperature for 1.0 h. The mixture was frozen and poured into 60 mL of saturated ammonium chloride solution and then extracted with 30 mL of CH2Cl2. The organic layer was washed with brine and dried (Na2SO4). After filtration, the residue was purified by flash column chromatography on silica gel, with hexane-EtOAc, 9:1 as the eluent, to give pure (4) in 93% yield.
The synthetic route of 171290-52-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lara-Ochoa, Francisco; Sandoval-Minero, Leticia C.; Espinosa-Perez, Georgina; Tetrahedron Letters; vol. 56; 44; (2015); p. 5977 – 5979;,
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