Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34967-24-3, name is 3,5-Dimethoxybenzyl amine, A new synthetic method of this compound is introduced below., Recommanded Product: 34967-24-3
To 3 mL of methanol solution containing 30 mg of 7-methoxy-4-methyl-1-(2-(4-oxocyclohexyl)ethyl)quinolin-2(1H)-one, 16 mg of 3,5-dimethoxybenzylamine, 8 muL of acetic acid and 9 mg of sodium cyanoborohydride were added, and the mixture was allowed to stand overnight after stirred at room temperature for 1 hour. To the reaction mixture, chloroform and aqueous saturated sodium hydrogen carbonate solution were added, the organic layer was separated, washed with aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue thus obtained was purified by flash silica gel column chromatography [gradient elution of chloroform : methanol=90 : 10-80 : 20], to give 22 mg of 1-(2-(4-((2,4-dimethoxybenzyl)amino)cyclohexyl)ethyl)-7-methoxy-4-methylquinolin-2(1H)-one as a yellow oil. 1H-NMR (CDCl3) delta: 1.00-1.80 (7H, m), 1.88-2.04 (2H, m), 2.20-2.75 (3H, m), 2.41 (3H, s), 3.78-3.83 (2H, m), 3.79 (6H, s), 3.91 (3H, s), 4.20-4.30 (2H, m), 6.42-6.45 (3H, m), 6.77-6.85 (2H, m), 7.14-7.18 (1H, m), 7.61 (1H, d, J=9.0 Hz)
The synthetic route of 34967-24-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TOYAMA CHEMICAL CO., LTD.; TAISHO PHARMACEUTICAL CO., LTD; EP1900732; (2008); A1;,
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