63057-72-7, name is 1-(Benzyloxy)-4-bromo-2-methoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1-(Benzyloxy)-4-bromo-2-methoxybenzene
General procedure: n-BuLi (10.7 mmol, 1.6 M solution in hexanes) was slowly added at -78 C under N2 atm to a stirred solution of 1a (10.2 mmol) in THF (25 mL) then stirred for 30 min at the same temperature. Aldehyde 2a (11.3 mmol) in THF (25 mL) was added dropwise over a period of 5 min then the reaction mixture was stirred for 30 min at -78 C. The reaction mixture was allowed to warm to 0 C, quenched with saturated NH4Cl solution, and extracted into ethyl acetate. The organic layer was dried over anhydrous Na2SO4, and the solvents were evaporated. The crude compound was purified by column chromatography (35% EtOAc/hexane) to get alcohol 3a as off-white solid (yield 55%).
The synthetic route of 63057-72-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pericherla, Kasiviswanadharaju; Shirazi, Amir Nasrolahi; Kameshwara Rao; Tiwari, Rakesh K.; Dasilva, Nicholas; McCaffrey, Kellen T.; Beni, Yousef A.; Gonzalez-Sarrias, Antonio; Seeram, Navindra P.; Parang, Keykavous; Kumar, Anil; Bioorganic and Medicinal Chemistry Letters; vol. 23; 19; (2013); p. 5329 – 5331;,
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