Synthetic Route of 33170-72-8, The chemical industry reduces the impact on the environment during synthesis 33170-72-8, name is 2-Bromo-1,1-dimethoxypropane, I believe this compound will play a more active role in future production and life.
A mixture of compound 2-bromofuranylpropionaldehyde dimethyl acetal (1.0 g, 4.74 mmol) and hydrochloric acid (1 M, 3 mL) was heated to 90C and stirred for 1 hour. The reaction solution was cooled to room temperature and then neutralized to pH of 7 with a solid of sodium bicarbonate. Then 2-amino-5-bromopyridine (360 mg, 2.08 mmol) and methanol (5 mL) were added successively, and the reaction solution was heated to 90C and stirred overnight. The reaction solution was evaporated under reduced pressure to remove the organic solvent, diluted with water (10 mL) and dichloromethane. The organic layer was seperated, washed with water, saturated brine, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give a crude product, which was purified by silica gel column chromatography to give compound 31-a as a gray solid (250 mg, 57%). LC-MS (ESI): m/z = 210.9 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1,1-dimethoxypropane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Yingli Pharmaceutical Co. Ltd.; XU, Zusheng; LOU, Yangtong; CHEN, Li; (95 pag.)EP3492461; (2019); A1;,
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