Synthetic Route of 592-55-2, A common heterocyclic compound, 592-55-2, name is 1-Bromo-2-ethoxyethane, molecular formula is C4H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound A2 (0.13 mmol, 50 mg), and 1-BROMO-2-ETHOXY-ETHANE (0.65 mmol, 99 mg) were dissolved in DMF (1 ML) and triethylamine (0.91 mmol, 127 GEL). The reaction was heated in a microwave at 80C for 20 minutes. The mixture was quenched with water and extracted with ethyl acetate. Removal of organic solvent in vacuo and purification by prep-TLC provided Compound A12 as a yellow solid (20 mg, 33%).’H NMR (400 MHz, CDC13) 8 (PPM) : 10.06 (s, 1H), 8.29 (s, 1H), 7.84 (d, 2H), 7.74 (d, 2H), 5.39 (s broad, 1H), 3.53 (M, 2H), 3.39 (q, 2H), 2.86 (s, 3H), 2.77 (M, 2H), 2.65 (M, 3H), 2.04 (M, 2H), 1.92 (m, 3H), 1.09 (M 3H). LCMS (ESI), m/z 466.3 (M+H+, 100%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2005/7647; (2005); A1;,
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