Application of 74654-07-2,Some common heterocyclic compound, 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, molecular formula is C7H17NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of 2 (1000 mg, 1.33 mmol), 1,3-dicyclohexylcarbodiimide (140 mg, 2.03 mmol), and allylamine (150 mg, 2.33 mmol) in 50 cm3 of dichloromethane and 1-hydroxybenzotriazole hydrate (225 mg, 1.46 mmol) dissolved in 15 cm3 of tetrahydrofuran were mixed together and stirred at 0 C for 1 h. After this time, the reaction mixture was stirred at room temperature for a further 24 h. Then the solvents were distilled under reduced pressure to dryness. The residue was suspended in hexane and filtered off to remove the 1,3-dicyclohexylurea by-product. The filtrate was evaporated under reduced pressure and purified by Dry Column Vacuum Chromatography on silica gel (Fluka type 60) to give 3a as a colourless solid (893 mg, 85% yield). Pure compound 3a was dissolved in acetonitrile. The solution was allowed to evaporate at room temperature. After several days the crystals were formed in 57% yield.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, its application will become more common.
Reference:
Article; Huczynski, Adam; Janczak, Jan; Stefanska, Joanna; Antoszczak, Michal; Brzezinski, Bogumil; Bioorganic and Medicinal Chemistry Letters; vol. 22; 14; (2012); p. 4697 – 4702;,
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