Synthetic Route of 103291-07-2, These common heterocyclic compound, 103291-07-2, name is 4-Bromo-1-fluoro-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of arylbromide (1.0 eq), magnesium turnings (1.1 eq) and a catalytic amount of iodine in anhydrous THF was stirred for 2h at 60C under argon. A solution of the appropriate aldehyde in anhydrous THF was added and the reaction mixture was stirred at 80C. The end of the reaction was monitored by TLC. The mixture was quenched with brine and extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, filtered and evaporated to dryness under reduced pressure. The crude product was purified by column chromatography.
Statistics shows that 4-Bromo-1-fluoro-2-methoxybenzene is playing an increasingly important role. we look forward to future research findings about 103291-07-2.
Reference:
Article; Braun, Florian; Bertoletti, Nicole; Moeller, Gabriele; Adamski, Jerzy; Frotscher, Martin; Guragossian, Nathalie; Madeira Girio, Patricia Alexandra; Le Borgne, Marc; Ettouati, Laurent; Falson, Pierre; Mueller, Sebastian; Vollmer, Guenther; Heine, Andreas; Klebe, Gerhard; Marchais-Oberwinkler, Sandrine; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 61 – 76;,
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