Application of 767-91-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 767-91-9, name is 2′-Methoxyphenyl acetylene, This compound has unique chemical properties. The synthetic route is as follows.
Cuprous iodide (9.5 mg, 0.05 mmol) was weighed out,Sodium carbonate (530 mg, 5 mmol),Tetrabutylammonium nitrite (288 mg, 1 mmol) and 2-methoxyphenylacetylene (132 mg, 1 mmol) were sequentially added into a 25 mL reaction vessel and the mixture was purged with nitrogen three times. Purified THF (4.0 mL), charged with CO2 (0.1MPa). Closed reactor, placed in a 25 C oil bath reaction 16h, after the reaction, open the valve on the reactor slowly release the remaining gas, and then the reaction vessel was transferred to a single port flask to concentrate, and with 5mL of deionized water Diluted and then extracted with n-hexane. The aqueous layer was acidified to pH = 1 at low temperature by addition of 1 M hydrochloric acid and extracted with ether. The organic phase was collected, washed with brine, dried over anhydrous sodium sulfate, filtered and the solvent removed in vacuo. 2-Methoxyphenylacetophenic acid was obtained in a yield of 83%.
The chemical industry reduces the impact on the environment during synthesis 2′-Methoxyphenyl acetylene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Dalian University of Technology; Feng Xiujuan; Jia Lihong; Bao Ming; (19 pag.)CN107353194; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem