Electric Literature of 13940-96-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13940-96-0, name is 4-Phenoxybenzene-1,2-diamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of Intermediate AC (395 mg,1 .97 mmol) in EtOH (10 mL) was added 1,3- bis(methoxycarbonyl)-2-methyl-2-thiopseudourea (427 mg,2.07 mmol),and the mixture was heated to reflux for 18h. After cooling to r.t.,Eta0 was added and the resultant solid collected by filtration (washing with EtOH/Et20) to afford the title compound as an off-white solid (436 mg,78%).1H NMR 6H (500 MHz,DMSO-d6) 11 .61 (br s,2H),7.40 (d,J = 8.5 Hz,1 H),7.38 – 7.32 (m,2H),7.09 – 7.03 (m,2H),6.97 – 6.92 (m,2H),6.81 (dd,J = 8.5,2.4 Hz,1 H),3.75 (s,3H); LCMS (Method A): 3.24 min,(284.2,MH+).
The synthetic route of 4-Phenoxybenzene-1,2-diamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLOBACHEM NV; URCH, Christopher, John; JACKSON, Victoria, Elizabeth; JORDAN, Linda; BURGIN, Ryan, Neil; (180 pag.)WO2019/141980; (2019); A1;,
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