Synthetic Route of 19056-40-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19056-40-7 as follows.
Reference 2; Synthesis of 3-methoxy-4-(2-methylpyridin-4-yl)benzenamineStep l4-Bromo-3-methoxyaniline (3.70 g, 18.3 mmol; Aldrich) was dissolved in N,N- dimethylformamide (40 mL, 500 mmol) and triethylamine (2.68 mL, 19.2 mmol) was added. Acetic anhydride (1.81 mL, 19.2 mmol) was added and the reaction mixture stirred for 5 hours. The reaction mixture was diluted with water and extracted with diethyl ether. The organic layer was dried over Na2SO4, filtered and diluted with hexames. The layer was concentrated to minimal volume and the resultant slurry was filtered and washed with hexanes to yield N-(4- bromo-3-methoxyphenyl)acetamide as a light peach solids.
According to the analysis of related databases, 19056-40-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; WO2009/75874; (2009); A1;,
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