Synthetic Route of 67191-35-9,Some common heterocyclic compound, 67191-35-9, name is 1-Isopropoxy-2-vinylbenzene, molecular formula is C11H14O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A 50 mL two-necked flask was replaced with argon followed by the addition of ligand 8 (10 mmol, 8a, 8b, 8c, 8d, 8e, 8f, 8g, or 8h), CuCl (30mmol, 3eq) and 25mL of dry dichloromethane (DCM). ), after replacing it three times with argon gas, the closed system was protected with an argon balloon. The ruthenium complex 4a (10 mmol) was added under argon atmosphere, and reacted at room temperature for 1.0 hour. Until the raw material 4a. After the reaction was completed, the silica gel was added to the filtrate, and the crude product was obtained by silica gel column chromatography, and then purified by washing with methanol or pentane-DCM to obtain a green solid product 9 (10 mmol, 9a, 9b, 9c, 9d, 9e, 9f, 9g, or 9h).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Isopropoxy-2-vinylbenzene, its application will become more common.
Reference:
Patent; Zannan Science And Technology (Shanghai) Co., Ltd.; Zhan Zhengyun; (19 pag.)CN109134547; (2019); A;,
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