Related Products of 36942-56-0,Some common heterocyclic compound, 36942-56-0, name is 2-Bromo-4-methoxy-1-methylbenzene, molecular formula is C8H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 2: (4-Bromo-2-methoxy-5-methylphenyl)(4-fluorophenyl)methanone4-Fluorobenzoyl chlo?de (1.40 mL, 11.9 mmol) was added dropwise to a suspension ofAlCl3 (1.73 g, 13.0 mmol) in 1 ,2-dichloroethane (30 mL) at room temperature. After 15 mm a solution of 3-bromo-4-methylanisole (2.17 g, 10.8 mmol) in 1 ,2-dichloroethane (3 mL) was added dropwise. The resulting mixture was stirred for 2 h, poured into 200 mL of ice-water, stirred for 20 min and extracted with CHCl3 (3x). The combined organics were washed with 5% aq. NaHCO3, brme, d?ed (Na2SO4) and concentrated. The residue was subjected to chromatography on silica gel (EtOAc-hexane, 5:95) affording the title compound. 1H NMR (500 MHz, acetone-^): delta 7.86 (m, 2H), 7.38 (s, IH), 7.31-7.26 (m, 3H), 3.76 (s, 3H), 2.39 (s, 3H).
The synthetic route of 36942-56-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2006/99735; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem