Application of 24332-20-5,Some common heterocyclic compound, 24332-20-5, name is 1,1,2-Trimethoxyethane, molecular formula is C5H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 3: (E)-5-((5,6-dimethoxypyridin-3-ylimino)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione A round bottom flask was charged with 2-methoxyacetaldehyde dimethyl acetal (2076 mul, 2076 mumol) and 2,2-dimethyl-1,3-dioxane-4,6-dione (299 mg, 2076 mumol). The flask was fitted with a reflux condenser and the mixture was heated at 100 C. for 2 h under nitrogen. 5,6-Dimethoxypyridin-3-amine (320 mg, 2076 mumol) was added, and within a minute a solid had precipitated out of solution. The heterogeneous mixture was heated at 100 C. for 10 min. The mixture was cooled to RT and the solids were filtered and washed with hexanes. (E)-5-((5,6-dimethoxypyridin-3-ylimino)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione was isolated as a yellow/orange solid. MS [M+H]=309.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,2-Trimethoxyethane, its application will become more common.
Reference:
Patent; CEE, Victor J.; DEAK, Holly L.; DU, Bingfan; GEUNS-MEYER, Stephanie D.; HUA, Zihao; MARTIN, Matthew W.; MARX, Isaac; NGUYEN, Hanh Nho; OLIVIERI, Philip R.; PANTER FABER, Kathleen; ROMERO, Karina; SCHENKEL, Laurie; WHITE, Ryan; US2014/336182; (2014); A1;,
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