Synthetic Route of 22483-09-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22483-09-6 as follows.
A solution of aminoacetaldehyde dimethyl acetal (25 mL, 229 mmol) in toluene (120 mL) is treated at 0 C with a 4.85 M sodium hydroxide solution (70.8 mL, 343.5 mmol). The mixture is stirred at 0 C for 10 minutes and benzyl chloroformate (33.8 mL, 229 mmol) is added keeping the internal temperature below 20 C during the addition. The mixture is warmed to room temperature over 4 hours. The organic layer is separated, washed with brine, dried over sodium sulfate, and concentrated to dryness to give the title compound (54 g, 98 %). ES/MS (m/e): 240 (M+H).
According to the analysis of related databases, 22483-09-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ELI LILLY AND COMPANY; GREEN, Steven James; MERGOTT, Dustin James; WATSON, Brian Morgan; WINNEROSKI JR., Leonard Larry; WO2014/143579; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem