Application of 93919-56-3,Some common heterocyclic compound, 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, molecular formula is C8H8F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirred solution of 5-chloro-2-ethylpyrazolo[1,5-a]pyridine-3-carboxylic acid or 2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxylic acid (1.34mmol) in DMF (20mL) was added EDCI (0.39g, 2.01mmol), HOBt (91mg, 0.67mmol) and Et3N (0.68g, 6.7mmol) at room temperature. After 1h of stirring, 1a-8a (1.34mmol) was added and the reaction was heated to 80C for overnight. The mixture was cooled, and diluted with EA (50mL), washed with water and brine, dried with Na2SO4 and concentrated. The crude product was purified by flash chromatography to afford the title compounds1-8.
The synthetic route of 93919-56-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lu, Xiaoyun; Tang, Jian; Cui, Shengyang; Wan, Baojie; Franzblauc, Scott G.; Zhang, Tianyu; Zhang, Xiantao; Ding, Ke; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 41 – 48;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem