Electric Literature of 7664-66-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7664-66-6, name is 4-Isopropoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 19 Preparation of 4-(4-chlorobenzyl)-2-dimethyl-amino-5-(4-isopropoxyphenylamino)pyrimidine (I-181) To a mixture of 5-bromo-2-(methylthio)pyrimidine (600 mg, 2.92 mmol), tris(dibenzylideneacetone)(0)-chloroform (303 mg, 0.293 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (169 mg, 0.293 mmol), cesium carbonate (1.91 g, 5.85 mmol) and dioxane (13 mL) was added 4-isopropoxyaniline (531 mg, 3.51 mmol) under nitrogen atmosphere, and the resulting mixture was stirred at 90 C. for 18 hours. The reaction mixture was poured into water (200 mL), and the mixture was extracted with ethyl acetate (100 mL*3). The extract was washed by brine (100 mL), dried over anhydrous magnesium sulfate, and concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (methanol/dichloromethane and ethyl acetate/hexane). The resulting residue was precipitated by dichloromethane and hexane to give 5-(4-isopropoxyphenylamino)-2-(methylthio)pyrimidine (5.24 g, Yield: 65%) as yellow powder. 1H-NMR (DMSO-d6): 1.24 (6H, d, Hz), 2.46 (3H, s), 4.49 (1H, sept, J=6.0 Hz), 6.85 (2H, d, J=9.0 Hz), 7.02 (2H, d, J=9.0 Hz), 8.06 (1H, s), 8.34 (2H, s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Isopropoxyaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SHIONOGI & CO., LTD.; Kai, Hiroyuki; Endoh, Takeshi; Jikihara, Sae; Horiguchi, Tohru; US9212130; (2015); B2;,
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