Reference of 645-36-3,Some common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, molecular formula is C6H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 35 g of P8 in 354 ml of MeOH (methanol) was added 3.5 ml of AcOH (acetic acid). The solution was mixed with 33 ml of aminoacetaldehyde diethylacetal at room temperature and stirred for 3-4 hrs. After the solution was cooled to 10 s C, 3.3 g of the reducing agent NaBH4 (sodiumborohydride) was slowly added thereto. At this time, care had to be taken because of hydrogen gas generation and exothermal reaction. The solution was stirred at room temperature for 1 hr. When the reaction was completed, 354 ml of EA (ethylacetate) and 354 ml of distilled water were added so as to separate layers. The organic layer thus formed was dried over 141 g of MgSO4 (magnesium sulfate) and crystallized in hexane to afford 85 g of P7 as a yellowish solid (yield 80%) . 1H NMR (500MHz, CDCl3), delta 8.36 (d, J=4.8 Hz, IH), delta 7.61 (s, IH), delta 7.17 (d, J=4.2 Hz, IH), delta 7.10 (d, J=4.2 Hz, IH), delta 4.58 (t, J=3.3, IH), delta 4.21 (s, 3H), delta 4.07 (s, 3H), delta 3.68 (m, 2H), delta 3.51 (m, 2H), delta 2.82 (d, J=3.3 Hz, 2H), delta 2.48 (s, 3H), delta 1.19 (t, J=4.2 Hz, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2-Diethoxyethanamine, its application will become more common.
Reference:
Patent; CHOONGWAE PHARMA CORPORATION; WO2010/120112; (2010); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem