Synthetic Route of 3616-56-6,Some common heterocyclic compound, 3616-56-6, name is 2,2-Diethoxy-N,N-dimethylethanamine, molecular formula is C8H19NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under the protection of nitrogen, take 6mol / L hydrochloric acid 10.0ml, down to 0 ,9.0 ml of compound III ((dimethylamino) -acetaldehyde-diethyl acetal) was added dropwise, hydrolyzed at 40 ° C and cooled to 0 ° C for standby (A).To 100 ml of absolute ethanol, 10.00 g of the intermediate IV, 0.80 g of lithium chloride were added in this order, and the temperature was lowered to 04.0 g of sodium ethoxide was added, and the mixture was stirred for 30 minutes. The stock solution A was added dropwise, and the prepared liquid A was added dropwise.After the reaction was continued for 40 min, 250 ml of ethyl acetate was added, stirred for 1.0 hr, filtered, and 125 ml of water was added to the filtrate. In ThereThe organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to give intermediate II. The yield in this step was about 84percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2-Diethoxy-N,N-dimethylethanamine, its application will become more common.
Reference:
Patent; Chongqing Weipeng Pharmaceutical Co., Ltd.; Lie, Zeyan; Zhou, Xingguo; Li, Chunlin; Han, Gongchao; (6 pag.)CN104529800; (2017); B;,
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