Synthetic Route of 19056-40-7, These common heterocyclic compound, 19056-40-7, name is 4-Bromo-3-methoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of 4-bromo-3-methoxyaniline (25 g, 124 mmol) in concentrated HCl (1.7 L) cooled to O0C was added sodium nitrite (11.1 g, 161 mmol) in water (250 mL) slowly over 30 minutes, keeping the temperature below 80C. After stirring for 2 hours, KJ (61.6 g, 371 mmol) in water (250 mL) was added to the resulting orange solution slowly over 30 minutes, keeping the temperature below 8C. The mixture was then warmed to RT and stirred a further 1.5 hours. The mixture was then filtered through a sintered glass wool funnel. The resulting solid was dissolved in EtOAc (1.2 L) and washed with water, 0.5 N NaOH, aqueous sodium bisulfite, and brine. The organic layer was then dried over Na2SO4 and filtered through a pad of silica, and then solvent was removed in vacuo. The crude material was purified on silica (100% hexanes) to yield the title product.
The synthetic route of 19056-40-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2008/57208; (2008); A2;,
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