Some common heterocyclic compound, 450-91-9, name is 4-Fluoro-2-methoxyaniline, molecular formula is C7H8FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Fluoro-2-methoxyaniline
Taking 200 ml 98 wt % sulfuric acid is added to a 500 ml three-port flask, ice water bath cooled to 5 – 10 C, then addition of 2 – methoxy -4 – fluoro aniline (41.0g, 0 . 29 muM), control of speed of addition, the reaction solution maintained at a temperature of 0 – 20 C; then adding KNO batch3(34.4g, 0 . 34 muM), keep the temperature of the reaction solution is 0 – 20 C, after adding the reaction liquid natural temperature to 25 C, reaction 2h end after. The reaction liquid slowly poured into the 1L the ice water, stirring after filtering out the solid, the filtrate 40 wt % NaOH to pH=9 and in, dropwise lye process is maintained in the temperature not higher than 40 C, after adding stirring 1h, separating solid, after the solid is filtered, washed with water solid to neutral, then dried to obtain the brown body solid 2 – methoxy -4 – fluoro -5 – nitroaniline 40.5g, yield is 75.2%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 450-91-9, its application will become more common.
Reference:
Patent; Shanghai University of Engineering Science; Sun, Mingchen; Mao, Yongjun; Zhang, Rui; Liu, Xiangyu; Wang, Han; (14 pag.)CN106366022; (2017); A;,
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