In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 74654-07-2 as follows. name: 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine
3′-Amino-6 ‘- (tert-butoxycarbonylamino)Spiro [isobenzofuran-1 (3H), 9 ‘- [9H] xanthene]-3-one(100 mg, 0.23 mmol) was dissolved in dichloromethane (2.0 mL), 2,6-lutidine (0.11 mL, 0.93 mmol) was added and cooled to 0 C. Triphosgene (31 mg, 0.12 mmol) was added and stirred at 0 C. for 30 min,After further reacting at room temperature for 1 hour,[2- [2- (2-methoxyethoxy) ethoxy] ethyl] amine (105 mg, 0.46 mmol) was added and reacted as such for 1 hour.After diluting the reaction solution with ethyl acetate (100 mL)The organic layer was washed with 1 M hydrochloric acid (50 mL), saturated aqueous sodium hydrogen carbonate solution (50 mL)And saturated brine (50 mL) in this order, and dried over anhydrous sodium sulfate.The solvent was distilled off under reduced pressure,The obtained residue was purified by silica gel chromatography (chloroform,Then 50% ethyl acetate / chloroform) to giveSpiro [isobenzofuran-1 (3H), 9 ‘- [9H (3H), 3’ – [[2- [2- (2-methoxyethoxy) ethoxy] ethyl] aminocarbonylamino] ] Xanthen] -3-one (130 mg, yield 90%) as a yellow solid.
According to the analysis of related databases, 74654-07-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CD: Tosoh Corporation; Satoru: Sgami Chemical Research Institute; Inoe, So Sen; Araki, Hiroshi; Miki, Daisuke; Futami, Itaru; Saijou, Satoshi Bun; (65 pag.)JP2017/222609; (2017); A;,
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