September 3,2021 News Analyzing the synthesis route of 19056-40-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19056-40-7 as follows. HPLC of Formula: C7H8BrNO

3-Methoxy-4-bromoaniline (10.0 g, 0.0494 mol) and dimethylacetylene dicarboxylate(7.46 g, 0.0525 mol) were combined in methanol (71 mL) and Dowtherm (140 mL) and refluxed under nitrogen for 18 hrs. The reaction was cooled and concentrated to give an oily residue and additional Dowtherm (20 mL) was added. This solution was added dropwise via syringe to Dowtherm (120 mL) at 250 0C and allowed to stir at 250 0C for an additional 15 min (precipitate observed). The reaction mixture was cooled to room temperature, solids filtered and washed with hexanes to give 14.4 g solid. EPO The solid was resuspended in dichloromethane (200 mL) and stirred for 30 min. The solid was filtered to give to give 34 (13.8 g, 90percent yield). LRMS (M+H)+ = 312.

According to the analysis of related databases, 19056-40-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2006/119061; (2006); A2;,
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