Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53087-13-1, name is 1-(Benzyloxy)-3-bromobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 53087-13-1
A solution of 1-(benzyloxy)-3-bromobenzene (for a preparation see Intermediate 21 , 263 mg, 1.0 mmol) in 1 ,4-dioxane (8 mL) was added to a mixture of £>/s(pinacolato)diboron (1 .27 g, 5.0 mmol), potassium acetate (392 mg, 4.0 mmol) and [1 ,1 – t)/’s(diphenylphosphino)ferrocene]dichloropalladium(ll), (PdCI2(dppf)) (37 mg, 5 mol%). The reaction mixture was heated in a microwave at 1 10C for 60 minutes. The cooled reaction mixture was diluted with ethyl acetate (20 mL) and filtered through Celite. The filtrate was dried and evaporated to give 2-(3-(benzyloxy)phenyl)-4,4,5,5-tetramethyl-1 ,3,2-dioxaborolane (310 mg, 1.000 mmol, 100 in the next step without further
The synthetic route of 53087-13-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AMANS, Dominique; BAMBOROUGH, Paul; BARKER, Michael David; BIT, Rino Antonio; BROWN, John Alexander; CAMPBELL, Matthew; GARTON, Neil Stuart; LINDON, Matthew J; SHIPLEY, Tracy Jane; THEODOULOU, Natalie Hope; WELLAWAY, Christopher Roland; WESTAWAY, Susan Marie; WO2014/140077; (2014); A1;,
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