Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks
Synthesis of (S)-(-)-1-(4-hydroxyphenyl)ethylamine hydrobromide (6) A solution of (S)-(-)-1-(4-methoxyphenyl)ethylamine (5, 75 g, 496.7 mmol) in 30% hydrogen bromide in acetic acid (350 mL, Aldrich) in a 1 liter sealed tube was heated at 100-110 C. in an oil bath for 6 hours. The reaction was cooled to room temperature, and nitrogen gas was bubbled into the solution to purge the excess HBr (the HBr was purged into aqueous NaOH). Volatiles were then removed in vacuo to afford the crude phenol amine HBr salt 9 (110 g) as a brown oil, which was used in the next reaction without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Bristol-Myers Squibb Company; US2008/9534; (2008); A1;,
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