Application of 39021-83-5, These common heterocyclic compound, 39021-83-5, name is 1,4-Dimethoxy-2,3-dimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-(bromomethyl)-1,4-dimethoxy-3-methylbenzeneInto a 50-mL round-bottom flask, was placed a mixture of 1,4-dimethoxy-2,3-dimethylbenzene (1.00 g, 6.02 mmol, 1.00 equiv)(Example 128), CCl4 (20 mL), NBS (1.20 g, 6.74 mmol, 1.10 equiv) and BPO (145 mg, 0.57 mmol, 0.10 equiv). The solution was stirred for 16 h at 80 C. After concentration, the residue was diluted with 50 mL of TBME and washed with 3×20 mL of brine. The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure. This resulted in 1.20 g (81%) of 2-(bromomethyl)-1,4-dimethoxy-3-methylbenzene as a brown crude solid.
Statistics shows that 1,4-Dimethoxy-2,3-dimethylbenzene is playing an increasingly important role. we look forward to future research findings about 39021-83-5.
Reference:
Patent; Global Blood Therapeutics, Inc.; Li, Zhe; Xu, Qing; Yu, Chul; Yee, Calvin; Gwaltney,, II, Stephen L.; Metcalf, Brian W.; Richards, Steven; Lardy, Matthew A.; Setti, Lina; Sham, Hing; US2015/315198; (2015); A1;,
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