Electric Literature of 54149-17-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Under an argon atmosphere, sodium hydride (2.41g, 100 mmol) was suspended in THF (20 mL). Pyrrolidine (3.50 g, 50 mmol) dissolved in 30 mL of THF was added dropwise to the solution. The mixture was stirred at 25C for 15 h, then 1-bromo-2-(2-methoxyethoxy)ethane (9.15 g, 50 mmol) was added to the solution. After stirring at 70C for 15 h, the resulting suspension was filtered to remove the white precipitate. The solvent was removed from the filtrate by rotary evaporation to give the yellow crude product. The crude product was purified by distillation under reduced pressure. The fraction collected at 120C under a reduced pressure of 1 mm Hg afforded the pyrrolidine derivative 1-(2-(2-methoxyethoxy)ethyl)pyrrolidine (OE2py) as a colorless oil (yield=6.16 g, 72%). 1H NMR (CDCl3 relative to tetramethylsilane (TMS), 300 MHz): delta (ppm)=3.41 (m, 6H), 3.38 (s, 3H), 2.69 (t, J=5.2Hz, 2H), 2.55 (t, J=5.1Hz, 4H), 1.76 (m, 4H). MS (FAB+): m/z=174.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Horiuchi, Shunsuke; Zhu, Haijin; Forsyth, Maria; Takeoka, Yuko; Rikukawa, Masahiro; Yoshizawa-Fujita, Masahiro; Electrochimica Acta; vol. 241; (2017); p. 272 – 280;,
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