Reference of 19056-40-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19056-40-7, name is 4-Bromo-3-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To an ice cooled solution of 4-bromo-3-methoxyaniline (3.00 g, 14.85 mmol) in pyridine(20 mL) was added (E/Z)-3-ethoxyacryloyl chloride (2.98 g, 22.27 mmol) over a period of 5 mm.and stirred at RT for 16 h. After completion of the reaction, the reaction mixture was diluted with ice cooled water and extracted with EtOAC (150 mL x 2). The combined organic layer was washed with aq. iN HC1 (100 mL), water (150 mL), brine (100 mL), dried over sodium sulphate and concentrated. The residue was used for next step without further purification (3.20 g, 72percent).1H NMR (400 MHz, DMSO-d6): oe 9.86 (s, 1H), 7.54?7.42 (m, 3H), 7. 12?7.08 (m 1H), 5.50 (d,J=12.7 Hz, 1H), 3.95 (q, J=6.9 Hz, 2H), 3.80 (s, 3H), 1.27 (t, J=7.3 Hz, 3H); LC-MS: mlz 301.1(M+1).
The synthetic route of 4-Bromo-3-methoxyaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SAMAJDAR, Susanta; ABBINENI, Chandrasekhar; SASMAL, Sanjita; HOSAHALLI, Subramanya; WO2015/104653; (2015); A1;,
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