Adding a certain compound to certain chemical reactions, such as: 2734-70-5, name is 2,6-Dimethoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2734-70-5, Safety of 2,6-Dimethoxyaniline
To a solution of pentanenitrile (310 mg, 3.7 mmol) and 2-methoxy-6-methylaniline (518 mg, 3.40 mmol) in toluene (13 mL) at RT was added a solution of trimethylaluminum in toluene (1.7 mL, 3.4 mmol) at 0 °C. The reaction mixture was heated at 110 °C for 1 h. The cooled reaction mixture was quenched by the addition of a saturated solution of Rochelle’s salt (5 mL) and stirred at RT for 30 min. The reaction mixture was extracted with EtOAc (3×20 mL). The combined organic portion was washed with brine, dried over MgS04, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography elution with 20-100percent EtOAc hexanes to give Compound la (450 mg, 56percent) as a brown oil. LCMS (Method D) retention time = 0.65 min, m/z = 237.1 (M+H)+. NMR (500MHz, chloroFORM-d)? 6.88 (t, J=8.4 Hz, 1H), 6.51 (d, J=8.3 Hz, 2H), 4.68 – 3.89 (m, 2H), 3.71 (s, 6H), 2.33 (br. s., 2H), 1.84 -1.52 (m, 2H), 1.49 -1.24 (m, 2H), 0.89 (br. s., 3H).
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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; TORA, George, O.; FINLAY, Heather; JIANG, Wen; MENG, Wei; ZHANG, Xiaojun; (303 pag.)WO2017/218633; (2017); A1;,
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